2010European Journal of Medicinal ChemistryDOI: 10.1016/j.ejmech.2010.02.007

A novel series of cytotoxic iridoid glucosides derived from aucubin: Design, synthesis and structure–activity relationships

Publication Authors

Vokatsoa C. Rakotondramasy, Christine Mouriès, Xavier Cachet, Abdelhak Neghra, Missam El Mourabet, François Tillequin, Michel Koch, Brigitte Deguin

Faculty Researcher

1 researcher

Vokatsoa Christian RAKOTONDRAMASY

Maitre de Conférences

Abstract

Abstract & synthèse du document

Five new unsaturated iridolactones 3–7 related to natural cytotoxic oxylipins, Tei 9826, and iridolactone 2, were prepared by parallel synthesis from natural aucubin. It was found that perpivaloyl iridoid glucosides 2, 3, and 4 were markedly cytotoxic against both L1210 and KB-3-1 cell lines.

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